Does this tier list change based on modifiers?

Yes, the article notes that items and trinkets, such as the Fan Amulet and Mr Boom Amulet, can significantly change the effectiveness of weapons.

How high were these builds tested?

The builds were tested and reported to have consistent results up to Brine 15 solo.

Abyssus Best Weapons & Guns Tier List

Abyssus

Abyssus throws a lot at you, so knowing the best guns saves runs and time. This Abyssus tier list ranks every weapon from top clears and tested builds, focused on real performance in rooms and bosses.

Note: You can click here to see how to unlock all weapons.

Best Weapons & Guns, quick answer

S tier, Tesla Gun, Combat Bow, Plasma Launcher
A tier, Revolver, Fish Gun
B tier, Machinegun, Shotgun, Plasma Cannon
C tier, Pistol, Burst Machinegun

You can see more information on each down below.

S tier, Abyssus Best Weapons

Tesla Gun

Clears rooms fast with Spark Orbs spreading effects across packs.
Shadow works for damage sharing on elites, still weaker on pure single target.

Combat Bow

Upgrades can push rapid full auto and consistent crit chains.
Pairs well with Turret for a barrier setup, stays strong on bosses.

Plasma Launcher

Explosions scale hard with Fan Amulet and Mr Boom Amulet.
Blackhole attachments and distance based AoE upgrades make rooms trivial.

A tier, strong and reliable

Brine Revolver

High single target damage, great for bosses.
Lacks wide room control without heavy support.

Fish Gun

Primary scales with explosion trinkets and on reload effects.
Can produce bursty clears when additional projectiles and extra explosions stack.

B tier, usable with support

Engine Rifle

Good mix of speed and damage, steady pick for higher Brine.
Rarely the best choice, still serviceable with the right blessings.

Shotgun

Works for close range control.
Needs investment and positioning, outclassed by top AoE options.

Plasma Cannon

Reported as weak in both primary and secondary use.
Outdamaged by Bow and Chainsaw Fish in tests.

C tier, avoid for serious pushes

Pistol

Simple and fast, but poor scaling for long expeditions.
Outperformed by Revolver and Bow.

Burst Machinegun

Low output compared to other automatics.
Falls behind as enemy health scales.

Best synergies, weapons and builds

Tesla Gun setups

Spark Orbs for effect spread, Spirits or Fire for stacking damage.
Frost as ability helps with control, Shadow for shared pain on packs.

Plasma Launcher setups

Anchor for Freeze, then bonus damage to Frozen targets.
Fan Amulet, Mr Boom Amulet, distance based AoE, bounce, and triple shot stack well.

Bow setups

Turret with Barrier for passive safety while Bow shreds.
Late upgrades enable full auto feel with strong crit uptime.

Explosion focused runs

Additional Projectile Amulet, extra explosions on primary and reload, double explosion trinkets.
Works with Fish primary, works with Plasma Launcher, but visibility can get wild.

Notes on abilities and tools

Anchor

Freeze plus bonus damage to Frozen, strong boss help.

Turret

Barrier blessing for a safe Bow or Tesla plan.
Needs investment to shine, fine as a buffer in passive builds.

Cube, Ghost, Blood

Laser Cube with Ghost explosion, chain explosion upgrades, and Blood orb explode create heavy overload damage.
Rotation examples use ability into secondary, then rapid primary to drain.

How this Abyssus tier list was ranked

Based on shared runs and reports, including clears up to Brine 15 solo.
Weighted for room clear, boss damage, and scaling with common trinkets and blessings.
Names and combos reflect the terms used by players in live runs.

Final Blurb

The top Abyssus guns are Tesla Gun, Combat Bow, and Plasma Launcher, they clear rooms, scale with common trinkets, and still handle bosses with the right setup. Revolver and Fish Gun can carry, but they need the right pieces, lower picks work in a pinch, yet they fall off in longer dives.

FAQ

What is the best all around weapon right now

Tesla Gun for rooms, Combat Bow for balanced clears and bosses, Plasma Launcher for explosive maps.

What is the best boss killer

Revolver is the standout for single target, Bow and Plasma Launcher catch up with Freeze or smart setups.

Do modifiers and trinkets change this list

Yes, items like Fan Amulet, Mr Boom Amulet, and Additional Projectile Amulet can push Plasma Launcher or Fish into easy wins.

Is Turret worth using

Yes with Barrier for safety, but it needs investment if you want it to be a main damage plan.