Hollow Knight Silksong Lifeblood Guide: Plasmium Buds
Lifeblood makes its return in Hollow Knight: Silksong, though in Pharloom it goes by the name Plasmium. This mechanic is tied to a quest in the Wormways, where Hornet is tasked with gathering Plasmium Buds for Alchemist Zylotol. Completing the quest rewards you with the Plasmium Phial, a tool that works like Lifeblood in the original game, giving Hornet extra temporary masks of health.
How to Start the Lifeblood Quest
To begin the Lifeblood quest, you first need a Simple Key. The easiest one is sold in Bone Bottom for 500 Rosaries. You’ll also need the Cling Grip ability to navigate Wormways properly.
Head west of Mosshome until you reach the entrance to the Wormways. Past two large cages hanging in a gap, continue left until you find a locked door. Use the Simple Key to open it. Inside, climb upward through the Wormways until you reach Alchemist Zylotol, who gives you the quest to collect three Plasmium Buds.
Plasmium Bud Locations
First Bud
The first Plasmium Bud is found in the chamber directly below Zylotol. Equip the tool he provides at the nearby bench and head down to collect it. Watch out for worms bursting from the ground and ceiling. These can damage Hornet, but they can also be used to regen if you’re low on health.
Second Bud
The second bud is near the base of the Wormways where the area starts blending into Moss Grotto. Head east and then down until you see the green moss environment. At the end of a short corridor, you’ll find the bud. There’s also a shortcut here that links back into Moss Grotto, making travel easier.
Third Bud
The final Plasmium Bud is located in the southwest chamber of the Wormways. Move left from the westmost entrance until you find the bud near the far wall. Collect it to complete the quest objective.
Lifeblood Rewards: Plasmium Phial
Return to Zylotol with all three Plasmium Buds to receive the Plasmium Phial. This is a red tool that gives Hornet one extra mask of temporary health when activated.
The Plasmium Phial has three immediate uses and draws from a reserve of 20 charges. Sitting at a bench refills the phial from your reserve. Once the reserve is empty, you can revisit Zylotol for a paid refill using Rosaries.
This makes the Plasmium Phial a powerful survival tool, especially in boss fights, acting as Silksong’s version of Lifeblood masks.
Final Blurb
Lifeblood in Hollow Knight: Silksong is reimagined as Plasmium, obtained through Zylotol’s quest in the Wormways. By gathering three Plasmium Buds, you unlock the Plasmium Phial, a tool that provides temporary health masks. It’s a direct callback to Lifeblood from the first game and an essential survival option in Pharloom.
FAQ
What is Lifeblood in Silksong?
In Silksong, Lifeblood is called Plasmium. It functions the same way, granting Hornet extra temporary masks of health.
Where do you start the Lifeblood quest?
The quest begins in the Wormways after using a Simple Key to unlock the door west of Mosshome. You then meet Alchemist Zylotol.
How many Plasmium Buds are there?
You need to collect three Plasmium Buds: one near Zylotol, one at the base near Moss Grotto, and one in the southwest chamber of the Wormways.
What is the reward for completing the Lifeblood quest?
You receive the Plasmium Phial, a red tool that grants temporary masks of health, similar to Lifeblood in the first game.
Can the Plasmium Phial be refilled?
Yes. It has a reserve of 20 charges that refill at benches. When the reserve runs out, you can pay Zylotol to refill it.

