Indiana Jones and the Great Circle Collegial Mystery Guide
The Collegial Mystery in Indiana Jones and the Great Circle Order of the Giants DLC is one of the first puzzles you can find inside Casina Pio IV. Many players miss it because the game pushes you toward the main map puzzle, but solving this safe is worth the time. The reward includes secret documents and a combat adventure book.
How to Start the Collegial Mystery
Go upstairs in Casina Pio IV instead of focusing on the map. Enter the smaller room, then step into the larger room on the right. On the desk is Federico’s Letter, which officially begins the Collegial Mystery and points you toward the locked safe.
How to Get the Safe Code
To solve the safe, you need Alessandro’s Letter. Look under the first chair in the row of seats inside the larger room to find it. The note gives three clues that line up with paintings on the walls.
Apostles painting above the row of chairs shows 12 Apostles.
Nativity painting in the smaller room shows 2 Cherubim.
Prodigal Son painting on the right wall shows 2 Beasts.
Combine the numbers and the safe code is 1222.
Collegial Mystery Rewards
Open the safe and you will receive two hidden documents and the Hard Crust combat adventure book. The book provides an extra collectible tied into the DLC’s lore. The documents expand the backstory behind the Order of Giants and give extra flavor to the mystery.
Final Blurb
The Collegial Mystery in Indiana Jones and the Great Circle Order of the Giants is a short but clever side puzzle that rewards you for slowing down. By grabbing Federico’s Letter, following Alessandro’s clues, and matching the paintings, you crack the code 1222 and unlock unique rewards.
FAQ
Where is the Collegial Mystery found?
It is upstairs inside Casina Pio IV at the start of the Order of the Giants DLC.
How do you start the Collegial Mystery?
Pick up Federico’s Letter from the desk in the larger upstairs room.
What is the safe code for the Collegial Mystery?
The safe code is 1222.
What rewards are inside the safe?
You get two hidden documents and the Hard Crust combat adventure book.
Can this puzzle be missed?
Yes, if you continue with the main map puzzle without exploring upstairs, you will miss the Collegial Mystery.

