Slay the Spire 2 Potions Guide: Full List And Best Potions

Potions in Slay the Spire 2 are powerful single use tools that can turn the tide of a fight. Some potions deal instant damage, others provide block or energy, and a few can completely save a run during dangerous encounters.

Because potions are limited and cannot be used every turn, knowing which ones are strongest and when to use them is extremely important. Some potions are simple utility items, while others can create massive combo turns against elites or bosses.

You can click here to jump to the full list of potions and their effects

What Potions Do In Slay the Spire 2

Potions are single use items that provide powerful instant effects during combat.

You can carry a limited number of potions at a time. When used, the potion activates immediately and then disappears.

Potion effects vary widely. Some provide damage or defense, while others generate cards, energy, or special mechanics that can dramatically change a turn.

Saving strong potions for elite fights or bosses is often the difference between winning and losing a run.

Best Potions In Slay the Spire 2

Some potions provide far more impact than others, especially in difficult fights.

S Tier Potions

These potions can completely change the outcome of a fight.

Fairy in a Bottle
Duplicator
Liquid Memories
Gigantification Potion
Bottled Potential
Entropic Brew

Fairy in a Bottle prevents death and restores health, making it one of the safest potions in the game. Duplicator and Gigantification Potion can create massive damage turns, while Liquid Memories allows you to replay key cards when you need them most.

A Tier Potions

Very strong potions that provide powerful utility.

Lucky Tonic
Shackling Potion
Fortifier
Radiant Tincture
Clarity Extract
Stable Serum
Distilled Chaos
Droplet of Precognition

These potions improve consistency, defense, or energy generation during important fights.

B Tier Potions

Useful potions that depend more on deck situation.

Attack Potion
Skill Potion
Power Potion
Swift Potion
Energy Potion
Gambler's Brew
Touch of Insanity
Blessing of the Forge

These potions generate extra cards or resources but are less predictable than the strongest options.

C Tier Potions

Simple potions with smaller effects.

Fire Potion
Explosive Ampoule
Block Potion
Strength Potion
Dexterity Potion
Weak Potion
Vulnerable Potion
Flex Potion
Speed Potion

These are still helpful but usually provide smaller advantages compared to higher tier potions.

Character Specific Potions

Some potions are tied to specific characters and mechanics.

Ironclad Potions

Ashwater
Blood Potion
Soldier's Stew

Silent Potions

Cunning Potion
Ghost in a Jar
Poison Potion

Defect Potions

Focus Potion
Essence of Darkness
Potion of Capacity

Necrobinder Potions

Bone Brew
Potion of Doom
Pot of Ghouls

Regent Potions

Cosmic Concoction
King's Courage
Star Potion

These potions interact directly with each character’s mechanics and abilities.

Full Slay the Spire 2 Potion List and Effects

Ashwater | Exhaust any number of cards in your hand.

Attack Potion | Choose 1 of 3 random Attack cards to add to your hand. It is free to play this turn.

Beetle Juice | Enemy attacks deal 30 percent less damage for the next 4 turns.

Blessing of the Forge | Upgrade all cards in your hand for the rest of combat.

Block Potion | Gain 12 Block.

Blood Potion | Heal for 20 percent of your maximum HP.

Bone Brew | Summon 15.

Bottled Potential | Shuffle all cards into your draw pile and draw 5 cards.

Clarity Extract | Draw 1 card. At the start of your next 3 turns draw 1 additional card.

Colorless Potion | Choose 1 of 3 random Colorless cards to add to your hand. It is free to play this turn.

Cosmic Concoction | Add 3 upgraded Colorless cards into your hand.

Cunning Potion | Add 3 upgraded Shiv cards into your hand.

Cure All | Gain Colorless Energy and draw 2 cards.

Dexterity Potion | Gain 2 Dexterity.

Distilled Chaos | Play the top 3 cards of your draw pile.

Droplet of Precognition | Choose a card in your draw pile and add it to your hand.

Duplicator | Your next card played this turn is played an additional time.

Energy Potion | Gain Colorless Energy.

Entropic Brew | Fill all empty potion slots with random potions.

Essence of Darkness | Channel a Dark orb for each of your orb slots.

Explosive Ampoule | Deal 10 damage to all enemies.

Fairy in a Bottle | When you would die this potion is consumed and you heal to 30 percent of your maximum HP.

Fire Potion | Deal 20 damage.

Flex Potion | Gain 5 Strength this turn. Lose 5 Strength at the end of the turn.

Focus Potion | Gain 2 Focus.

Fortifier | Triple your current Block.

Foul Potion | Deal 12 damage to everyone. Can be thrown at the Merchant for 100 Gold.

Fruit Juice | Gain 5 Max HP.

Fysh Oil | Gain 1 Strength and 1 Dexterity.

Gambler's Brew | Discard any number of cards then draw that many.

Ghost in a Jar | Gain 1 Intangible.

Gigantification Potion | Your next Attack deals triple damage.

Glowwater Potion | Exhaust your hand and draw 10 cards.

Heart of Iron | Gain 7 Plating.

King's Courage | Forge 15.

Liquid Bronze | Gain 3 Thorns.

Liquid Memories | Return a card from your discard pile to your hand. It costs 0 energy this turn.

Lucky Tonic | Gain 1 Buffer.

Mazaleth's Gift | Gain 1 Ritual.

Orobic Acid | Add a random Attack, Skill, and Power to your hand. They are free to play this turn.

Poison Potion | Apply 6 Poison.

Pot of Ghouls | Add 2 Souls into your hand.

Potion of Binding | Apply 1 Weak and 1 Vulnerable to all enemies.

Potion of Capacity | Gain 2 Orb slots.

Potion of Doom | Apply 33 Doom.

Potion-Shaped Rock | Deal 15 damage.

Powdered Demise | Enemy loses 9 HP at the end of each of its turns.

Power Potion | Choose 1 of 3 random Power cards to add to your hand. It is free to play this turn.

Radiant Tincture | Gain Colorless Energy. Gain an additional Colorless Energy at the start of your next 3 turns.

Regen Potion | Gain 5 Regen.

Shackling Potion | All enemies lose 7 Strength this turn.

Ship in a Bottle | Gain 10 Block. Next turn gain 10 Block.

Skill Potion | Choose 1 of 3 random Skill cards to add to your hand. It is free to play this turn.

Snecko Oil | Draw 7 cards. Randomize the cost of cards in your hand this turn.

Soldier's Stew | All cards containing Strike gain 1 Replay this combat.

Speed Potion | Gain 5 Dexterity this turn. Lose 5 Dexterity at the end of the turn.

Stable Serum | Retain your hand for 2 turns.

Star Potion | Gain Regent Star Energy.

Strength Potion | Gain 2 Strength.

Swift Potion | Draw 3 cards.

Touch of Insanity | Choose a card in your hand. It is free to play this combat.

Vulnerable Potion | Apply 3 Vulnerable.

Weak Potion | Apply 3 Weak.

Final Blurb

Potions are one of the most underrated tools in Slay the Spire 2. A single well timed potion can save a run, finish a boss, or create a powerful combo turn.

Learning which potions have the biggest impact and saving them for difficult encounters will dramatically improve your success rate.