Slay the Spire 2 Boss Relics: Full List and Best Picks

Relics are one of the biggest power spikes in Slay the Spire 2. A strong relic can stabilize a weak deck or push a good one into boss killing territory. The wrong relic can quietly sabotage a run while you wonder why Act 2 suddenly feels impossible.

This tier list ranks relics based on how much they improve an average run. Some relics scale damage, some improve card draw, and others simply keep you alive long enough to win.

Slay The Spire 2 Relics Tier List

S Tier Relics

These relics are run defining. If one appears, it is almost always correct to take it.

Ice Cream | Unspent energy carries over between turns which allows huge combo turns and removes wasted energy completely.
Mummified Hand | Playing a Power reduces the cost of another card in your hand which can create extremely powerful turns in scaling decks.
Bag of Preparation | Draw two extra cards on the first turn which greatly improves early turn consistency in every fight.
Gambling Chip | Discard and redraw your starting hand which fixes bad opening hands and prevents early damage.
Paper Phrog | Vulnerable causes enemies to take much more damage which dramatically increases burst damage potential.

A Tier Relics

These relics are extremely strong and help most decks but are slightly more situational than S tier picks.

Tungsten Rod | Reduce all HP loss by one which blocks chip damage from burns, thorns, and multi hit attacks.
Lantern | Gain one extra energy on turn one which helps stabilize difficult elite fights.
Ornamental Fan | Gain Block after playing three attacks which provides free defense in aggressive decks.
Lizard Tail | Revive once with half health which acts as a powerful safety net in dangerous fights.
Paper Krane | Weak reduces enemy damage more than usual which makes defensive strategies much stronger.

B Tier Relics

These relics provide steady value but usually will not carry a run by themselves.

Pen Nib | Every tenth attack deals double damage which can create strong burst turns if managed carefully.
Vajra | Gain one Strength permanently which improves attack scaling across the entire run.
Oddly Smooth Stone | Gain one Dexterity which improves every block card you play.
Thread and Needle | Start combat with Plated Armor which gives passive block each turn.
Anchor | Start combat with ten Block which helps absorb early damage.

C Tier Relics

These relics are situational or provide weaker benefits compared to other options.

Tiny House | Provides small bonuses including gold, potion, and a card upgrade but none of them are strong enough to change a run.
Dream Catcher | Resting heals additional health but upgrading cards at campfires is usually more valuable.
Girya | Gain Strength by using rest sites which delays card upgrades and often slows scaling.

D Tier Relics

These relics can actively harm your run unless you have a very specific strategy.

Greed’s Purse | Grants gold on kills but costs energy which slows combat tempo.
Glass Cannon | Doubles incoming damage which becomes extremely dangerous in later acts.

Relics That Become Strong With Specific Characters

Some relics are average normally but extremely strong with certain characters.

Ironclad

Red Skull | Gain Strength when below half health which works well with Ironclad aggressive builds.
Self Forming Clay | Gain Block whenever you lose HP which pairs with self damage mechanics.

Silent

Snecko Skull | Apply extra Poison whenever Poison is applied which greatly increases poison scaling.
Kunai | Gain Dexterity after multiple attacks which Silent can trigger easily.

Defect

Data Disk | Start combat with extra Focus which boosts Orb damage immediately.
Emotion Chip | Passive Orb effects trigger when taking damage which can create powerful turns.

Regent

Lunar Pastry | Boosts Royal abilities which are central to Regent builds.

Necrobinder

Bone Flute | Improves summon abilities which strengthens Necrobinder scaling.

Final Blurb

Relics often determine the success of a run in Slay the Spire 2. The strongest relics improve consistency, energy efficiency, and scaling throughout long fights.

Pay attention to relic synergy with your character and deck. A relic that looks average at first glance can become incredibly powerful when paired with the right build.

FAQ

What are the best relics in Slay the Spire 2

Ice Cream, Gambling Chip, Bag of Preparation, and Mummified Hand are some of the strongest relics because they improve consistency and scaling across most runs.